Acute generalized exanthematous pustulosis - Pustulosis Exanthematous Umum Akut
Pustulosis Exanthematous Umum Akut (Acute generalized exanthematous pustulosis) (AGEP) mangrupikeun réaksi kulit anu jarang anu dina 90% kasus aya hubunganana sareng administrasi obat. pustulosis exanthematous umum akut (acute generalized exanthematous pustulosis) dicirikeun ku letusan kulit ngadadak anu muncul rata-rata lima poé sanggeus nginum obat dimimitian. Letusan ieu mangrupa pustula, nyaéta bitu leutik beureum bodas atawa beureum dina kulit anu ngandung bahan mendung atawa purulen (nanah). Lesi kulit biasana ngabéréskeun dina 1-3 dinten saatos ngeureunkeun nginum obat anu ngalanggar.
☆ Dina hasil Stiftung Warentest 2022 ti Jerman, kapuasan konsumen sareng ModelDerm ngan ukur langkung handap tibatan konsultasi telemedicine anu mayar.
Lesions nyebar kalawan erythema na pustules muncul dumadakan.
References
Acute generalized exanthematous pustulosis (AGEP) nyaéta réaksi kulit anu ditandaan ku benjolan leutik anu pinuh nanah dina dasar kulit beureum. Biasana kajadian nalika aya jalma nginum obat-obatan anu tangtu, sapertos antibiotik, sareng gancang nyebar ka sakuliah awak. Saatos ngeureunkeun nginum obat anu nyababkeun, gejala biasana ngaleungit dina dua minggu, sering nyéépkeun kulit. Sanaos biasana henteu serius sareng dugi ka kulit, kasus parna tiasa diklasifikasikeun sareng réaksi kulit anu serius sapertos Stevens-Johnson syndrome atanapi toxic epidermal necrolysis #. Pangobatan utamina mangrupikeun perawatan anu ngadukung, sareng prognosis pikeun résolusi lengkep panyakit biasana saé.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Lalaki 76 taun sumping ka kamar darurat kusabab kulitna parantos robih dina dua dinten kapengker. Dokter mendakan bintik-bintik beureum sareng ngangkat daérah dina kalapa sareng panangan sareng sukuna. Salaku waktu nuluykeun, patches ieu ngagabung babarengan, sarta anjeunna ngembangkeun jarawat-kawas nabrak di wewengkon beureum. Tés nunjukkeun jumlah sél getih bodas anu luhur sareng seueur jinis anu disebut neutrofil, sareng tingkat paningkatan C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
